Peppone LJ, Huston AJ, Reid ME et al.
The effect of various vitamin D supplementation regimens in breast cancer patients.
Breast Cancer Res Treat. 2011 May;127(1):171-7.
Read free full text at PubMed Central.
Investigators at University of Rochester Medical Center and Roswell Park Cancer Institute undertook a retrospective study of 224 women diagnosed with stage 0–III breast cancer to (1) to assess vitamin D status and (2) evaluate the effect of daily low-dose and weekly high-dose vitamin D supplementation on 25-OH vitamin D levels.
They found that “weekly high-dose supplementation significantly increased 25-OH vitamin D levels, while daily low-dose supplementation did not significantly increase levels.” They also found that vitamin D deficiency and insufficiency were common among women with breast cancer and was associated with reduced BMD in the spine.
The paper includes a review of epidemiologic data indicating that vitamin D deficiency is associated with an increased incidence of breast cancer, that low vitamin D levels are associated with increased breast cancer recurrence and mortality rates, and that breast cancer patients are at increased risk for a number of medical
complications associated with vitamin D deficiency including bone loss, falls, fractures and infection.
In conclusion, they state:
“It is imperative that breast cancer patients maintain optimal vitamin D levels to minimize the risk of treatment-related problems such as bone loss, arthralgias, and falls. Clinicians need to carefully consider the vitamin D regimen (amount and type) when treating vitamin D deficiency in breast cancer patients due to the limited efficacy of daily low-dose supplementation.”
Read free full text at PubMed Central.
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