Calculating the Economic Value of Rainforest Preservation: Botanical Ethnomedicines

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Rainforest pharmacopeia in Madagascar provides high value for current local and prospective global uses

Christopher D. Golden, B. J. Rodolph Rasolofoniaina, E. J. Gasta Anjaranirina, Lilien Nicolas, Laurent Ravaoliny, and Claire Kremen
PLoS One
2012;7(7)
PubMed Central PMCID: PMC3407148
Makira Protected Area in Madagascar
Makira Protected Area in Madagascar (Source: Code REDD)

Researchers at Harvard University Center for the Environment, Madagascar Health and Environmental Research, University of California and Maroantsetra District Public Hospital calculated the economic value of botanical ethnomedicines in a rainforest region of Madagascar, the Makira Protected Area ([Code REDD] [Ministère de l’Environnement et des Forêts]).

From the introduction:

“The Malagasy’s use of ethnomedicines is not formalized into a traditional system of medicine with codified pharmacopeias (like Ayurvedic or Chinese ethnomedicine) but is transmitted by oral means and learned through participatory approaches. The majority of medicinal treatments fall into this category but a small fraction of treatments are reserved for the truly specialized spiritual healer, called ombiasa. The repertoire of medicines found in Madagascar is highly complex with a diverse range of species and treatment types. Providing a detailed monetary valuation of this ecosystem provisioning service will lend perspective to public health specialists, conservation planners, natural resource managers, and development agencies regarding the local importance of this service. Here we compare the value of this service to potential bioprospecting revenue and the UN-sponsored REDD (Reduced Emissions from Deforestation and Degradation) program to better understand the latent value of this ethnoknowledge and provide further evidence for supporting tropical forest conservation.”

The authors found that the great majority (>90%) of people living in the Makira rainforest area use botanical ethnomedicines, accessing them on average once a week. By matching the treated illnesses with a Western medicine counterpart when possible, the team calculated mean benefits of ethnomedicines per year at approximately USD 5.40–7.90 per person, USD 30.20–44.30 per household, and between USD 756,050–1,110,220 for all residents. Regarding potential value of the Makira rainforest area through the lens of commercial pharmaceutical development, based on a calculation of 1 to 18 potentially novel drugs derived from ethnomedicines used in the area, and using current average sales value of novel FDA-approved pharmaceuticals, the authors estimate that the protected area “could hold between $316 million to almost $6 billion of untapped revenue within its botanical diversity.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

My Way of Journalism

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Integrating markets and missions
Around the world, governments and businesses increasingly look to civil society for new ideas to support sustainable and responsible economic growth. At the same time, nongovernmental not-for-profit organizations are working, often with constrained budgets, to fill human and environmental needs unmet by existing governmental policies and business models.

In addition to my broad topic areas of health, art, and social progress, I have a special interest in the intersection of pharmaceutical science, ethnomedicine and the intellectual property rights of indigenous people.

Method
My epistemological method derives from “As We May Think,” a 1945 article by Vannevar Bush, President Roosevelt’s science advisor during World War II. Bush’s idea eventually led to the development of the hyperlink and the World Wide Web.

Materials
Open-access references are essential to my work. First among these is PubMed Central, the free full-text archive of biomedical and life sciences journal literature maintained by the US National Institutes of Health’s National Library of Medicine. Selected additional references broaden my information-base to include topics in art and social progress.

Endangered Ethnomedicinal Plant Demonstrates Anti-Mosquito Properties

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Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis

Rajendra Maharaj, Vinesh Maharaj, Neil R Crouch, Niresh Bhagwandin, Peter I Folb, Pamisha Pillay, and Reshma Gayaram
Malar J
2012 Sep 10;11:320
PubMed Central PMCID: PMC3472289

Investigators from the South African Medical Research Council, CSIR and University of KwaZulu-Natal undertook a study to establish whether any South African ethnomedicinal plants used traditionally to repel or kill mosquitoes demonstrate effective mosquito larvicidal properties.

Toddalia asiatica
Deforestation is making the ethnomedicinal plant Toddalia asiatica vulnerable to extinction (Nabwami J et al, African Crop Science Conference Proceedings 8: 2057-2061, 2007). (Photo source: Wikimedia Commons User Vinayaraj)

The authors tested 381 crude plant extracts, consisting of plants found native or naturalized in southern Africa, for their larvicidal effect on Anopheles arabiensis. They successfully identified one plant, Toddalia asiatica, that demonstrated superior larvicidal activity and that is now being further studied with the goal to isolate the active compound and develop a malaria vector control tool.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Valerie Green’s Dance Entropy in Begin. Again

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22 February 2014
LaGuardia Performing Arts Center
Long Island City, New York

After dancing in her formative years with the Erick Hawkins Dance Company, Valerie Green founded her own company, Dance Entropy, to create multi-ethnic stage and site-specific works that blend creation, performance and education to incubate new forms of dance from the Green Space, Ms. Green’s base in Long Island City.

Considering Dance Entropy’s vital role in linking dance and community, LaGuardia Performing Arts Center (located in The International High School at LaGuardia Community College) was a good choice of venue for the weekend’s ambitious program, featuring a performance of Ms. Green’s powerful 2013 dance theater piece Skimming The Surface: Fragments of Collective Unconscious along with premieres of her multimedia solo work Womb and a multi-act ballet, Hinge.

Skimming the Surface
Skimming the Surface: Fragments of Collective Unconscious (Photo: Yui Kitamara)

Skimming the Surface: Fragments of Collective Unconscious (2013), is a sharply focused expressionist drama featuring four dancers (Hana Ginsburg Tirosh, Kristin Licata, Yayoi Suzuki, Raleigh Veach). A bare lightbulb illuminates a blue room framed by two opaque windows, and scattered with four chairs and a table in disarray. Four characters inhabit this chilling space, and knives come out. [Stop – no spoilers in this post!]

Womb
Womb (Photo: Rodney Zagury)

In collaboration with photographer/videographer Rodney Zagury, Ms. Green performed a mesmerizing solo, Womb (premiere), realistically channeling the fluid movements of a fetus in the amniotic sac. Previously recorded projections of the dancer on two planes of vision added layers of epistemological challenge to a new form of dance experience utilizing natural body mechanics to produce a heightened aesthetic effect.

Hinge
Hinge (Photo: Yui Kitamara)

Hinge (premiere), a pure dance piece for six dancers (Emily Diers, Hana Ginsburg Tirosh, Kristin Licata, Yayoi Suzuki, Raleigh Veach, and Laureen Elizabeth in a standout performance), was accompanied by a brilliant composition by Yui Kitamara played live on stage by MuSE (Multicultural Sonic Evolution): Wanzhen Li (violin); Chihiro Shibayama and Jared Soldiviero (percussion).

In his curtain-raiser, LaGuardia Performing Arts Center managing director Steven Hitt introduced Ms. Green as a valuable resource to the LIC community. I would expand that to include the world of dance and the potential of one choreographer to improve the lot of humanity, starting with the artist’s home base.

Knowledge of Medicinal Plants on the Island of Bougainville

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An ethnobotanical survey of medicinal plants used in the Siwai and Buin districts of the Autonomous Region of Bougainville

Julie Waruruai, Beuluah Sipana, Michael Koch, Louis R. Barrows, Teatulohi K. Matainaho, Prem P Raia
J Ethnopharmacol
2011 Nov 18;138(2):564-77
PubMed Central PMCID: PMC3245962
Bougainville Island, Papua New Guinea
Bougainville Island, Papua New Guinea (Source: Wikimedia Commons User: Electionworld)

As part of a program initiated by the University of Papua New Guinea to systematically document and preserve traditional knowledge of medicinal plant use, researchers at University of Papua New Guinea and University of Utah undertook an ethnobotanical survey in the Siwai and Buin Districts of the Island of Bougainville.

From the Introduction:

“Initially settled around 40,000 years ago, extended habitation in diverse environs has rendered most ethnic groups in [Papua New Guinea] rich in medicinal plant knowledge. The traditional use of medicinal plants constitutes an important and threatened information reservoir that has been empirically tested and adopted through millennia of trial and error, but that is threatened by on-going development and change of lifestyle. Prior to the current University of Papua New Guinea  Traditional Medicines Database Surveys, two of which are reported here, [Papua New Guinea] medicinal plant use and corresponding pharmacological assessment was not systematically studied. The documentation of medicinal plants in [Papua New Guinea] has been haphazard and the accrued knowledge not widely disseminated internationally. We estimate that historically some 800 [Papua New Guinea] plants have been described in the literature for treatment of various ailments, but this represents only a fraction of the total number of plants actually utilized.”

The authors report that in Papua New Guinea respiratory problems, malaria and other infections, physical injury, diarrhea and obstetrical and gynecological difficulties are extremely common and many plants are used to treat these health problems.

Alstonia scholaris
Alstonia scholaris (Source: Wikimedia Commons User: Amar Chandra)

Of the medicinal plant species identified in the survey, 18 were found to used medicinally in the Siwai and Buin districts both, including six that are also harvested or cultivated for food: Barringtonia novae-hiberniae, Cocos nucifera, Ficus copiosa, Magnifera indica, Psidium guajava and Solanum torvum. Other plants used medicinally in both regions include Ageratum conyzoides, Alstonia scholaris, Angiopteris evecta, Ficus adenosperma, Hibiscus tiliaceus, Hornstedtia scottiana, Macaranga aleuritoides, Merremia peltata, Mikania micrantha, Mucuna novoguineensis, Premna serratifolia, and Pterocarpus indicus.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Plants of the Kedarnath Wildlife Sanctuary

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Ecological status and traditional knowledge of medicinal plants in Kedarnath Wildlife Sanctuary of Garhwal Himalaya, India

Jahangeer A Bhat, Munesh Kumar, Rainer W Bussmann
J Ethnobiol Ethnomed
2013 Jan 2;9:1
PubMed Central PMCID: PMC3560114
Kedarnath Wild Life Sanctuary entrance from Chopta
Kedarnath Wild Life Sanctuary entrance from Chopta (Source: Wikimedia Commons, Flikr user: Dirk Hartung)

Researchers at H.N.B. Garhwal University and Missouri Botanical Garden documented the traditional uses of medicinal plants, their ecological status and importance in Kedarnath Wildlife Sanctuary, the largest protected area of Garhwal Himalaya to serve as baseline information on medicinal plants and help strengthen the conservation of this important resource.

Podophyllum hexandrum
Podophyllum hexandrum (Source: Wikimedia Commons User: Pekaje)

The authors report 152 medicinally important plant species in the area, of which 18 species fall into the rare, endangered (critically endangered) and vulnerable status categories: Aconitium hetrophyllum, Picrorhiza kurrooa, Podophyllum hexandrum, Rosa sericea, Roscoea alpina, Salvia hians, Saussurea auriculata, Sorbus aucuparia, Sorbus cuspidata, Synotis alatus, Bistorta amplexicaulis, Coriaria nepalensis, Hypericum choisianum, Morina longifolia, Jurinea dolomiaea, Swertia chirayita, Polygonatum verticillatum and Zanthoxylum armatum.

From the Conclusions:

“Considering the ecological importance and population status of important ethnomedicinal species, we recommend the preparation of micro-plans for each important medicinal species, including data on best harvesting practice and quantity to be harvested. Most of this data is unknown for most medicinal plants. Propagation of plants using tissue culture techniques and conventional methods to allow for their transplantation into natural habitats and niche areas of the species will be an important step towards their conservation. Additional ecological studies, including population assessments using standard ecological methods are needed to effectively plan the conservation and management for threatened, rare and endangered species. The development of agro-production techniques for certain species of Garhwal Himalaya can help to meet the requirement of raw material for commercial use and reduce the pressure on the existing populations in natural habitats.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Plants of the Kavirajes

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A survey of medicinal plants used by Kavirajes of Chalna area, Khulna district, Bangladesh

Mohammed Rahmatullah, Dilara Ferdausi, Md Ariful Haque Mollik, Rownak Jahan, Majeedul H Chowdhury, Wahid Mozammel Haque
Afr J Tradit Complement Altern Med
2009 Dec 30;7(2):91-7
PubMed Central PMCID: PMC3021158
Khulna District, Bangladesh
Khulna District, Bangladesh (Source: Wikimedia Commons, Armanaziz adapted by Himalayan Explorer)

Researchers at the University of Development Alternative (Bangladesh) and New York City College of Technology conducted an ethnomedicinal survey amongst the Kavirajes (traditional healers) of Chalna area, Khulna district, Bangladesh, which is known to contain a diversity of medicinal plants. Information on 50 plant species was obtained, including plants used to treat skin diseases, intestinal tract disorders, cancer/tumor, rheumatoid arthritis, wounds (including tiger and snake bites), jaundice, diabetes, leprosy, sexually transmitted diseases, impotence, helminthiasis and heart disorders.

Barleria lupulina
Barleria lupulina (Source: Wikimedia Commons User: Biswarup Ganguly)

Prominent among those medicinal plants (ie, those used to treat four or more ailments) were Barleria lupulina, Hygrophila auriculata, Sansevieria trifasciata, Amaranthus spinosus, Spondias dulcis, Centella asiatica, Gnaphalium luteo-album, Tridax procumbens, Carica papaya, Brassica oleracea, Trichosanthes kirilowii, Excoecaria agallocha, Cassia fistula, Cassia occidentalis, Saraca indica, Sesbania grandiflora, Anisomeles malabarica, Clerodendrum inerme, Cuphea hyssopifolia, Psidium guajava, Cedrus deodara, Hygroryza aristata, Phragmites australis, Zea mays, Persicaria hydropiper, Richardia scabra, Murraya paniculata, Veronica officinalis and Boehmeria macrophylla.

From the discussion section:

Sundarbans
The Sundarbans (Source: Wikimedia Commons, SPOT Image)

“Our survey indicated that the plant species used for medicinal purposes in Chalna area differ from other areas of Bangladesh. However, the diseases treated by the Kavirajes of Chalna area were quite similar to diseases treated by Kavirajes in other regions of Bangladesh. One notable exception, as pointed out earlier, was the comparatively large number of plant species used to treat cancer. A number of the medicinal plant species are collected from the Sunderbans forest. Since depletion of this forest region is going on at an alarming rate, it is imperative that modern scientific studies be conducted as soon as possible on the medicinal plants of the area. Not only such scientific studies can lead to possible discoveries of novel pharmacologically active compounds, but also such discoveries can be an inducement for preservation of the forest region.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

An Unexpected Finding about Immigrants’ Knowledge of Medicinal Plants

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Globalization and loss of plant knowledge: challenging the paradigm

Ina Vandebroek, Michael J. Balick
PLoS One
2012;7(5). Epub 2012 May 25
PubMed Central PMCID: PMC3360753

To investigate the transnational dynamics of immigrants’ knowledge of medicinal plants  from their origin in the Dominican Republic to their new home in New York City, researchers from The New York Botanical Garden systematically queried participants on their knowledge of plants reported to treat 30 common health conditions.

Contrary to their initial hypothesis, and widely held belief among scholars, the authors found a significant and non-age-dependent increase in knowledge of medicinal plants among Dominicans living in New York City as compared to the Dominican Republic:

“The widely held paradigm is that plant knowledge declines with cultural change associated with modernization and globalization in many migrant and non-migrant communities world-wide. Our study demonstrated that cultural knowledge about medicinal plants in the context of a highly urbanized, transnational community in a globalized setting is kept alive and actively transformed by the geographic dynamics of that community. The increase in knowledge about food medicines in NYC was unexpected and is the first study to report a statistically measurable increase in this type of cultural knowledge associated with migration. We did not expect this to be the case in the NYC metropolis with its dramatically different ecological and social environment as compared to the DR, where people readily obtain medicinal plants free of charge from their backyards or surroundings. New Yorkers from Latino descent, however, operate a culturally-based healthcare system through botánicas that exists in parallel with the biomedical system.”

Among the health-policy implications of this finding is that ethnobotanists may have an important role to play in U.S. medical education.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Essential Oils Against Malaria

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Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area

Mario Dell’Agli, Cinzia Sanna, Patrizia Rubiolo, Nicoletta Basilico, Elisa Colombo, Maria M Scaltrito, Mamadou Ousmane Ndiath, Luca Maccarone, Donatella Taramelli, Carlo Bicchi, Mauro Ballero, Enrica Bosisio
Malar J
2012 Jul 2;11:219
PubMed Central PMCID: PMC3441327
Sardinia
Sardinia (Source: Wikimedia Commons User: TUBS)

Researchers at Università degli Studi di Milano, Università degli Studi di Cagliari, Università degli Studi di Torino and Laboratoire de Biologie Moléculaire undertook a screening study to evaluate the anti-plasmodial activity of aromatic plants traditionally used in Sardinia against malaria: Myrtus communis (myrtle, Myrtaceae), Satureja thymbra (savory, Lamiaceae), and Thymus herba-barona (caraway thyme, Lamiaceae).

The authors found evidence for the use of essential oils for treating malaria and fighting the vector at both the larval and adult stages, opening the possibility for further investigation aimed at the isolation of natural products with anti-parasitic properties.

From the discussion:

“Among the three plants, S. thymbra showed the highest in vitro anti-plasmodial activity, especially against the [Chloroquine]-resistant strain. Moreover, the time of collection (before, during, and after flowering) did not influence the anti-plasmodial effect, which appeared to be mainly associated with thymol, one of the components of the [Essential oil]. These results are in agreement with a recent report that the [Essential oil] of Oreganum compactum, rich in thymol, shows anti-plasmodial activity in vitro. Such a conclusion is corroborated by the data obtained with the [Essential oils] of M. communis and T. herba-barona since the latter, which does not contain thymol, possesses lower activity against P. falciparum. Moreover, the activity of thymol was selective against the parasites with low cytotoxicity against human dermal fibroblasts.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

A Better Way to Evaluate Antimalarial Plants Used in African Traditional Medicine?

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An alternative paradigm for the role of antimalarial plants in Africa

Steven Maranz
ScientificWorldJournal
2012;2012:978913. Epub 2012 Apr 19
PubMed Central PMCID: PMC3346345

Steven Maranz, a visiting scientist with the David H. Murdock Research Institute, proposes a shift from in vitro research into antimalarial plants used in African traditional medicine, and toward in vitro research. As stated in the abstract:

“Most investigations into the antimalarial activity of African plants are centered on finding an indigenous equivalent to artemisinin, the compound from which current frontline antimalarial drugs are synthesized. As a consequence, the standard practice in ethnopharmacological research is to use in vitro assays to identify compounds that inhibit parasites at nanomolar concentrations. This approach fails to take into consideration the high probability of acquisition of resistance to parasiticidal compounds since parasite populations are placed under direct selection for genetic that confers a survival advantage. Bearing in mind Africa’s long exposure to malaria and extensive ethnobotanical experimentation with both therapies and diet, it is more likely that compounds not readily overcome by Plasmodium parasites would have been retained in the pharmacopeia and cuisine. Such compounds are characterized by acting primarily on the host rather than directly targeting the parasite and thus cannot be adequately explored in vitro. If Africa’s long history with malaria has in fact produced effective plant therapies, their scientific elucidation will require a major emphasis on in vivo investigation.”

The author posits that a greater emphasis on in vivo testing would better capture the interaction between host, parasite and drug, and perhaps aid in the discovery of better long-term interventions.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.