Phase II Clinical Trial of Low-Dose Ipilimumab in Combination with Pembrolizumab for Melanoma That Has Spread to the Brain

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Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain

M.D. Anderson Cancer Center / Merck Sharp & Dohme Corp. / National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT03873818

The University of Texas MD Anderson Cancer Center
The University of Texas MD Anderson Cancer Center [Photo: National Cancer Institute]
Investigators at M. D. Anderson Cancer Center have opened a Phase II clinical trial to study the side effects and how well low-dose ipilimumab (YERVOY®, Bristol‑Myers Squibb) works in combination with pembrolizumab (KEYTRUDA®, Merck Sharp & Dohme) in treating patients with melanoma that has spread to the brain.

See additional details, including study location(s), eligibility criteria, contact information, and study results (when available) at ClinicalTrials.gov.

Send email to avery@williamaveryhudson.com for information about submitting qualified clinical trials for sponsored posts on this blog.




The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Uses of Wild Food Plants in Italy’s Middle Agri Valley

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Ethnobotanical survey of wild food plants traditionally collected and consumed in the Middle Agri Valley (Basilicata region, southern Italy)

Sansanelli S, Ferri M, Salinitro M, Tassoni A
J Ethnobiol Ethnomed. 2017 Sep 6;13(1):50
PubMed Central PMCID: PMC5586000

Investigators from the University of Bologna conducted an ethnobotanical survey in a scarcely populated area of Italy’s Middle Agri Valley to record local knowledge of the traditional uses of wild food plants, and to collect information regarding the medicinal uses related to these plants.

Asparagus acutifolius
Asparagus acutifolius [photo: Hectonichus, Wikimedia Commons]
Working with local informants, the team identified six species of wild food plants that were also noted for their therapeutic value: Asparagus acutifolius (kidney wellbeing), Cichorium intybus (liver wellbeing), Foeniculum vulgare (digestion), Glycyrrhiza glabra (feet sweating), Leopoldia comosa (soothing of burning eyes), and Sambucus nigra (stomachache).

The authors noted a relative paucity of reported medicinal properties of wild food plants in the region, which they attributed to a possible loss of ethnomedicinal knowledge:

“Some plant species previously reported … as phytoremedies, such as Laurus nobilis and Origanum vulgare, were also mentioned by the informants but only to be used as food and without any relation to possible therapeutic properties, indicating the loss of such knowledge over the years. This pattern was also confirmed by comparing the present results with other studies carried out few years ago in Basilicata region both among Italians and Arbëreshë communities. In particular, many species mentioned in the present research as having only food use, were previously indicated as also showing a medicinal application such as A. rusticana (anti-rheumatic), C. vitalba (heal mouth inflammation), C. cardunculus (anti-rheumatic, digestive), L. nobilis, F. carica, G. glabra, M. domestica and Z. jujuba (heal sore-throat), Rubus spp. and P. spinosa (hepato-protective), S. marianum (laxative), S. oleraceus (anti-gastritis), P. rhoeas (mild sedative)…. In addition, some species that have a well-known medicinal use in other parts of Italy, were not mentioned as having particular therapeutic effects in the Midlle Agri Valley. In particular, no medicinal properties were reported for Urtica spp., which in many other studies in Italy and abroad is known both as food and for medical use (refreshing, against kidney problems and for arthritis), and for Taraxacum officinale Weber and Sonchus spp., that have previously been defined as medicinal foods with both high nutritional values and depurative, blood cleaning and refreshing effects.”

Read the complete article at PubMed Central.

Send email to avery@williamaveryhudson.com for information about submitting qualified published research for sponsored posts on this blog.




The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.