Autophagy as a therapeutic target in cancer

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Chen N, Karantza V. Autophagy as a therapeutic target in cancer.
Cancer Biol Ther. 2011 Jan 15;11(2):157-68. PubMed PMID: 21228626.

Autophagy (“self-eating”), a process that maintains intracellular homeostasis and prolongs cell survival through recycling of amino acids and energy, is involved in many aspects of human health and disease, including cancer. The authors summarize current knowledge on the regulation and dual function of autophagy in the origin of tumors, as well as ongoing efforts in modulating autophagy for cancer treatment and prevention.

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