Beyond pathways

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Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis. 2010 Jan;31(1):2-8 [open access]

Two biomedical engineers at the University of Wisconsin and Massachusetts Institute of Technology review the literature to develop a critique of, and contribution to, pathway-centric oncogenesis research, toward a systems biology approach.

From the introduction:

“Pathways … cannot properly be considered to operate in isolation of one another, as an alteration of one pathway can lead directly (via protein–protein interactions) or indirectly (via transcriptional/translational influences) to changes in others. Accordingly, cancer—along with other complex diseases such as arthritis and diabetes—is most productively conceived of and strategized for treatment as a dysregulation of a multipathway network.”

Not the easiest paper, but well worth reading until you get it.