Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis. 2010 Jan;31(1):2-8 [open access]
Two biomedical engineers at the University of Wisconsin and Massachusetts Institute of Technology review the literature to develop a critique of, and contribution to, pathway-centric oncogenesis research, toward a systems biology approach.
From the introduction:
“Pathways … cannot properly be considered to operate in isolation of one another, as an alteration of one pathway can lead directly (via protein–protein interactions) or indirectly (via transcriptional/translational influences) to changes in others. Accordingly, cancer—along with other complex diseases such as arthritis and diabetes—is most productively conceived of and strategized for treatment as a dysregulation of a multipathway network.”
Not the easiest paper, but well worth reading until you get it.