Category Archives: Health

Beyond pathways

Share

Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis. 2010 Jan;31(1):2-8 [open access]

Two biomedical engineers at the University of Wisconsin and Massachusetts Institute of Technology review the literature to develop a critique of, and contribution to, pathway-centric oncogenesis research, toward a systems biology approach.

From the introduction:

“Pathways … cannot properly be considered to operate in isolation of one another, as an alteration of one pathway can lead directly (via protein–protein interactions) or indirectly (via transcriptional/translational influences) to changes in others. Accordingly, cancer—along with other complex diseases such as arthritis and diabetes—is most productively conceived of and strategized for treatment as a dysregulation of a multipathway network.”

Not the easiest paper, but well worth reading until you get it.

Global cancer burden to double, prevention urged

Share

Thun MJ, DeLancey JO, Center MM, et al. The global burden of cancer: priorities for prevention. Carcinogenesis. 2010 Jan;31(1):100-10. [open access]

Researchers from the American Cancer Society project that cancer deaths will more than double worldwide over the next 20-40 years, with the increase driven largely by growth and aging of populations in economically developing countries, in combination with tobacco use, an increase in obesity and physical inactivity, and prevalent chronic infections.

The authors recommend a number of preventive measures, including strengthened efforts in international
tobacco control and increased availability of vaccines against hepatitis B virus and human papilloma virus, along with “action-oriented translational research to adapt programs that have proven to be effective in high-income countries to every setting in which they are needed.”