Inhibitory Activity of Elderberry Extract Against Respiratory Bacterial Pathogens & Influenza A & B Viruses

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Krawitz C, Mraheil MA, Stein M, et al.
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
BMC Complement Altern Med. 2011 Feb 25;11:16.
Free full text via PubMed Central.

Investigators from Justus-Liebig-University analyzed a standardized liquid extract (Rubini, BerryPharma AG) from black elderberry (Sambucus nigra L.) for antimicrobial and antiviral activity for infections of the upper respiratory tract.

The article includes a historical review, highlighting references to elderberry as a therapeutic agent by Hippocrates, Theophrastus, Dioscorides, Galen, Hildegard von Bingen, Martin Blochwich, and Maud Grieves.

Based on an analysis using “a microtitre broth micro-dilution assay against three Gram-positive bacteria and one Gram-negative bacteria responsible for infections of the upper respiratory tract, as well as cell culture experiments for two different strains of influenza virus,” the authors conclude:

“Rubini elderberry liquid extract is active against human pathogenic bacteria as well as influenza viruses, both being clinically import groups of pathogens for which new and alternative therapeutic approaches are needed. In addition, bacterial super-infection during ongoing influenza virus infections complicates the situation for the patient. It would therefore be useful to simultaneously target both foes. The activities shown by the elderberry liquid extract suggest that additional and alternative approaches to influenza infections might be provided by natural products.”

The study was partially funded by BerryPharma AG.

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