Medicinal Plants against Dengue Fever


Potential anti-dengue medicinal plants: a review

Siti Latifah Abd Kadir, Harisun Yaakob, and Razauden Mohamed Zulkifli
J Nat Med
2013 Oct;67(4):677-89
PubMed Central PMCID: PMC3765846
Alternanthera philoxeroides
Alternanthera philoxeroides (Source: Wikimedia Commons, National Plant Data Center)

Researchers at Universiti Teknologi Malaysia reviewed potential anti- dengue fever activities from plants distributed around the world, finding 69 studies describing 31 species, including Alternanthera philoxeroides, Andrographis paniculata, Azidarachta indica, Boesenbergia rotunda, Carica papaya, Cladogynos orientalis, Cladosiphon okamuranus, Cryptonemia crenulata, Cymbopogon citratus, Euphorbia hirta, Flagellaria indica, Gymnogongrus griffithsiae, Gymnogongrus torulosus, Hippophae rhamnoides, Houttuynia cordata, Leucaena leucocephala, Lippia alba and Lippia citriodora, Meristiella gelidium, Mimosa scabrella, Momordica charantia, Ocimum sanctum, Piper retrofractum, Psidium guajava, Quercus lusitanica, Rhizophora apiculata, Tephrosia crassifolia, Tephrosia madrensis and Tephrosia viridiflora, Uncaria tomentosa, and Zostera marina.

From the conclusion:

“The development of new anti-dengue products from bioactive compounds is necessary in order to find more effective and less toxic anti-dengue drugs. Therefore, any extensive study on the potential of plants with isolated active compounds that have shown anti-dengue activity should go through additional in vitro and in vivo animal testing followed by toxicity and clinical tests. This route may reveal a promising compound to be optimized and thus be suitable for application in the production of new anti-dengue compounds. If pursued from drugs derived from medicinal plants around the continents, this work may prove valuable to the health of individuals and to nations. Moreover, such discoveries may lead to the development of highly efficient and safe anti-dengue treatments. However, to identify potential anti-dengue plants or compounds, knowledge of the mechanisms of virus infection need to be understood in order to facilitate the search for and development of the most appropriate drugs. Further research is needed to determine how to target the most appropriate stages to prevent the spread of virus infection. Focusing on each phase in the life cycle of the virus, new compounds could prevent (1) infection of host cells, (2) the viral maturation process, (3) synthesis of viral RNA, or (4) the spread of viral particles.”

Read the complete article at PubMed Central.

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