Pakistani Medicinal Plants as Antibacterial Agents against Escherichia coli


Ethnomedicinal and phytochemical review of Pakistani medicinal plants used as antibacterial agents against Escherichia coli

Adnan M, Bibi R, Mussarat S, Tariq A, Shinwari ZK
Ann Clin Microbiol Antimicrob. 2014 Aug 19;13:40
PubMed Central PMC4236513

Researchers from Kohat University of Science and Technology and Quaid-i-Azam University Islamabad conducted a review of literature on antibacterial activities of Pakistani medicinal plants against Escherichia coli, a gram-negative pathogen responsible for urinary tract and gastrointestinal infections in humans.

From the Introduction:

“Emergence of multiple drug resistant bacterial strains due to indiscriminate use of antibiotics has generated a keen interest in the discovery of effective plants derived drugs. E. coli are showing increased resistance to different antibiotics like amoxicillin and trimethoprim. Hence, searching of alternative and effective medicines from plants against such resistant bacteria has become an important concern all over the world. Antibiotics on one side became ineffective to bacterial strains but also costly for the poor communities of developing world. Furthermore, the antibiotics may be associated with adverse effects including hypersensitivity and immune suppression. Therefore, this review was designed with the aim to (i) compile the available fragmented literature on anti-E. coli effect of Pakistani medicinal plants, and (ii) suggest measures on newer and safer herbal drugs for the diseases caused by the E. coli. Furthermore, this review will provide knowledge on ethnomedicines and phytochemistry of those Pakistani medicinal plants having anti-E. coli potential. Above all, this review will provide baseline information for chemists, pharmacists and pharmacologists to carry out in-depth in-vitro and in-vivo activities for the development of novel drugs against E. coli with low cost and less side effects on living system.”

Althaea officinalis
Althaea officinalis [source: Wikimedia Commons – Franz Eugen Köhler, Köhler’s Medizinal-Pflanzen]
The authors report on 34 Pakistani medicinal plants with in-vitro anti-E. coli activity, including Althaea officinalis, Azadirachta indica, Calotropis procera, Carum copticum, Cichorium intybus, Cinnamomum zeylanicum, Cistanche tubulosa, Delonix regia, Dodonaea viscosa, Justicia adhatoda, Malva neglecta, Mentha longifolia, Viscum album and Withania somnifera.

Read the complete article at PubMed Central.

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