Tag Archives: malaria

Medicinal Plants of Eastern Madagascar

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Medicinal plants used to treat the most frequent diseases encountered in Ambalabe rural community, Eastern Madagascar

Rakotoarivelo NH, Rakotoarivony F, Ramarosandratana AV et al.
J Ethnobiol Ethnomed. 2015 Sep 15;11:68
PubMed Central: PMC4570514

Investigators from the Missouri Botanical Garden, University of Antananarivo, and Washington University in St. Louis inventoried medicinal plants used to treat diseases frequently occurring among residents of Ambalabe in eastern Madagascar.

Working with residents of Vatomandry District (which includes the rural community of Ambalabe and Vohibe Forest [a protected area established in 2008]), the team identified diarrhea, malaria, stomach-ache, cough, bilharzia (schistosomiasis), and dysentery as the most frequently occurring diseases and 83 medicinal plant species used to treat those diseases.

Litchi chinensis
Litchi chinensis [Photo: B.navez, WikiMedia Commons]
Plant species commonly used to treat the diseases included Mollugo nudicaulis, Litchi chinensis, Kalanchoe prolifera, and Paederia thouarsiana. Less than half of the medicinal plants were collected in Vohibe Forest, the rest were cultivated or collected around the villages, in house yards, and in crop fields.

In their conclusion, the authors note that while the local population retains important knowledge about medicinal plants, many of those species might be threatened:

“[T]his paper provides new information on medicinal plants used by the local population in Ambalabe community to fight against frequent diseases. Some species seemed new to sciences or sometimes have new uses never recorded. Further pharmacological studies will be needed to better understand the importance of traditional medicine. Besides, because 83 species were used to treat six most frequent diseases, their conservation should be considered as important to ensure sustainable future use, especially due to the fact that most of them were collected in the surroundings of the villages and in non-protected areas. Sustainable management techniques should be considered, especially for Malagasy endangered species.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.




Medicinal Plants Used by Traditional Healers in Zimbabwe for the Treatment of Malaria

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Medicinal plants used by traditional healers for the treatment of malaria in the Chipinge district in Zimbabwe

Ngarivhume T, Van’t Klooster CI, de Jong JT, Van der Westhuizen JH
J Ethnopharmacol. 2015 Jan 15;159:224-37
PubMed PMID 25449454

Researchers at Walter Sisulu University, University of Amsterdam and University of the Free State conducted an explorative ethnobotanical survey of the Chipinge district in Zimbabwe to document how malaria is conceptualized and diagnosed by traditional healers from the Ndau people, and to record the medicinal plants used in the prevention and treatment of malaria, their mode of preparation and administration.

Cassia abbreviata
Cassia abbreviata [Source: Jeppestown, Wikimedia Commons]
Based on interviews with 14 traditional healers from four villages (selected with the assistance of the headman of the Muzite area and a representative of the Zimbabwe National Traditional Healers Association), the team identified 28 plants used by the healers to manage malaria. Cassia abbreviata was the species cited most often, followed by Aristolochia albida and Toddalia asiatica.

The traditional healers, while aware of the pitfalls of appropriation, chose to work with the investigators:

“The healers were aware of the possibility of unfair bioprospecting practices from institutions such as pharmaceutical companies and were concerned about legal protection of their intellectual property and a possible lack of proper compensation, similar to the findings described by Uprety et al. (2012) amongst the aborigines of Canada. We were thus surprised by the absence of significant resistance from the healers to supply us with traditional knowledge and plant material. We attribute this to the involvement of the local headman and ZINATHA and the prior informed-consent forms that explained the objectives, benefits, risks and general procedures of the survey in Shona before the start of the project.”

In their conclusion, the authors suggest priorities for further research and development:

“The data gathered in this survey could assist in identifying plant species and extraction methods to develop herbal drugs against malaria in Zimbabwe. The most widely used plants for the treatment of malaria reported in this study such as Cassia abbreviata and Aristolochia albida should be prioritized for further research. In vitro screening programmes, based on this and other ethnobotanical study results, could be important in validating the traditional use of herbal remedies and for providing leads in the search for new active principles…. Scientific validation of herbal medicine may eventually lead to more widespread use of traditional medicines in cheaper health care systems, as in India and China, provided that thorough toxicological investigations, clinical studies and randomized controlled trials are carried out. African traditional knowledge and medicine thus have the potential to play a large role in primary healthcare, particularly in poor and isolated rural areas. This underscores the value of traditional knowledge and the need to collect and preserve traditional health practices.”

Read the complete article at PubMed.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Plants of the Ehotile People, Côte d’Ivoire

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Medicinal plants and traditional healing practices in ehotile people, around the aby lagoon (eastern littoral of Côte d’Ivoire)

Malan DF, Neuba DF, Kouakou KL
J Ethnobiol Ethnomed. 2015 Mar 14;11(1):21
PubMed Central PMC4391329

Aby Lagoon, Côte d’Ivoire
Aby Lagoon, Côte d’Ivoire [Source: J Ethnobiol Ethnomed. 2015; 11: 21]
Researchers from Université Nangui Abrogoua and Institut Botanique Aké-Assi d’Andokoi surveyed the ethnomedicinal knowledge of the Ehotile people, one of the smallest and oldest ethnic groups around the Aby Lagoon of Côte d’Ivoire.

The authors note that “the land occupied by Ehotile is one of the most degraded of the Ivorian Coast. Scarce natural vegetation that has withstood the plantations of coconut, oil palm or rubber is composed of the marshy patches and the islands of the Ehotile Islands National Park.”

The team documented 123 species employed by the Ehotile in the treatment of 57 diseases, including malaria, sexual asthenia, troubles linked to pregnancy, dysmenorrhea and hemorrhoids.

Ocimum gratissimum
Ocimum gratissimum [Source: Forest & Kim Starr, Wikimedia Commons]
Among the most salient medicinal species used were Harungana madagascariensis, Alstonia boonei, Ocimum gratissimum and Xylopia acutiflora. Exploitation for medicinal purposes of Harungana madagascariensis and certain other plant species has led to their scarcity or their disappearance.

From the conclusion:

“Despite the virtual disappearance of natural formations in Ehotile land, medicinal plants are important in the Ehotile health system. Medicinal plants are known and used alone or in addition to medical prescriptions to treat several ailments. However, some of them are becoming rare, and it is feared that this scarcity will result in the inevitable loss of associated knowledge and practices.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Formulations of Kuch Healers in Bangladesh

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Medicinal formulations of the Kuch tribe of Bangladesh

Rahmatullah M, Haque ME, Mondol MR, Hasan M, Aziz T, Jahan R, Seraj S
J Altern Complement Med. 2014 Jun;20(6):428-40
PubMed PMID: 24738615

Sherpur District of Bangladesh
Sherpur District of Bangladesh [source: Nafsadh, Wikimedia Commons]
Mohammed Rahmatullah and colleagues at the University of Development Alternative conducted an ethnomedicinal study to document medicinal formulations of tribal medicinal practitioners in the Kuch (also known as Koche or Koch) indigenous community of the Sherpur district of Bangladesh.

Interviews conducted with the help of a semi-structured questionnaire and guided field-walks resulted in documentation of 49 plants used in various preparations.

Justicia adhatoda
Justicia adhatoda [source: ShineB, Wikimedia Commons]
The team found similarity between use by Kuch healers and Indian traditional medicinal practice for 12 of the species: Justicia adhatoda, Acorus calamus, Costus speciosus, Mimosa pudica, Litsea glutinosa, Stephania glabra, Piper longum, Drynaria quercifolia, S. dulcis, Centella asiatica, Cissus quadrangularis, and Curcuma caesia.

The authors note the precarious existence of the community:

“The Kuch (otherwise known as Koche or Koch) tribe is a small indigenous community whose present territory includes primarily the Sherpur district and also scattered locations of the Rangpur, Dinajpur, Joypurhat, and Naogaon districts in northern Bangladesh. According to an 1872 population census, the tribal population numbered around 1 million and the tribe was then also present in the Pabna, Bogra, and Rajshahi districts of the country. In a population census conducted in 1913, the population was 156,000. The present population is estimated to be around 3000. Thus, there appears to have been a drastic decline in the tribal population in the last 140 years, which the Kuch attribute to frequent warfare and resulting moves to new areas. As result the tribe has had to adapt to their new places of residence, which is not easy because they face hostility from previous residents. Food shortage under these conditions leads to eventual decline in the economic status of the tribe, with consequent malnutrition, diseases, and mortality. In addition, the tribe faces continuous assimilation with the mainstream population….

“The Kuch, although they owned vast tracts of land in the past, are landless at present. They work as agricultural laborers in lands belonging to the mainstream Bengali-speaking population. As a consequence, their economic status is extremely poor. The men work in the fields and women supplement their family income by making various items from bamboo and selling them in the local village markets. Their main diet consists of rice consumed with dried fish and vegetables. Meat is primarily obtained from hunting rabbits, boars, and porcupines from forest areas. Fermented rice wine forms a major part of their diet and religious festivals. A favorite food is khaji or kanthamuri, which consists of steamed dried fish in combination with powdered rice and vegetables.”

The authors conclude that the medicinal plants of the Kuch tribe show potential for further scientific studies, particularly in research for treatments for malaria and, with limitations, diabetes.

Read the complete article at PubMed.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Plants Used by the Oromo People of Ethiopia’s Ghimbi District

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Medicinal plants used in traditional medicine by Oromo people, Ghimbi District, Southwest Ethiopia

Abera B
J Ethnobiol Ethnomed. 2014 May 8;10:40
PubMed Central PMCID: PMC4060869
Map of Ethiopia highlighting the Oromia Region
Map of Ethiopia highlighting the Oromia Region (Source: Wikimedia Commons User:Golbez)

Balcha Abera of Jimma University conducted an ethnobotanical study to identify the most effective medicinal plants used by the Oromo people of Ethiopia’s Ghimbi District, within the Oromia National Regional State.

Allium sativum
Allium sativum [source: William Woodville: „Medical botany“, London, James Phillips, 1793, Vol. 3 Plate 168: Allium sativum (Garlic), Wikimedia Commons]
Working with 30 key informants and 165 community members, Abera documented 49 medicinal plant species used to treat various human ailments, the majority of which were collected from the wild and the rest from homegardens. Three species demonstrated particularly high healing potential: Glinus lotoides (against tapeworm infection), Croton macrostachyus (against malaria), and Allium sativum (against malaria and other diseases).

Abera notes that the transfer of indigenous ethnobotanical knowledge in the region is declining from generation to generation, from a number of causes:

“Regarding the current transfer of indigenous knowledge [this study] confirmed that the traditional knowledge is declined from elder to younger age groups. On top of this, during specimen collection, interview and field visits elders express their interest by demonstration how to collect, process, administer, and prescribe medicinal plants and with great beliefs of the traditional medicine on its effectiveness on treating the diseases while the young generation showed low participation in all aspects. Thus, decreasing positive attitude towards use of medicinal plants in traditional medicine by young generation indicate the loss of vital indigenous knowledge…. Moreover, the decline of the traditional knowledge in generation is due to the … interference of and shifts to the use of more synthetic drugs not only in the urban but also extending to the rural areas…. Moreover, most of the African modern health professionals greatly undermine the contribution of traditional medicine in health care system while the scientists of developed nations intensively search for medicinal plants to seek a solution for the old and newly rising diseases. All these factors may result to a loss of this rich and useful knowledge which has been accumulated over many generations.”

He recommends incorporation of indigenous ethnobotanical knowledge into formal education before it is lost.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Traditional Use of Insect-Repellent Plants Against Malaria in Ethiopia

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Insect repellent plants traditional usage practices in the Ethiopian malaria epidemic-prone setting: an ethnobotanical survey

Karunamoorthi K, Hailu T
J Ethnobiol Ethnomed. 2014 Feb 12;10:22
PubMed Central PMCID: PMC3932844

Jimma Zone, southwest of Addis Ababa
Jimma Zone is southwest of Addis Ababa (center of map) [source: USAID/Ehiopia Map Room, Wikimedia Commons]
Kaliyaperumal Karunamoorthi and Teklu Hailu of Jimma University conducted an ethnobotanical survey to document and evaluate knowledge and usage practices of the local inhabitants on insect-repellent plants in Bechobore Kebele, Jimma Zone, Ethiopia, an area where malaria remains a leading cause of morbidity and mortality.

From the Background:

“In Ethiopia, burning of dried repellent plants is one of the common phenomena to drive away insects and mosquitoes. It is usually performed by using the traditional charcoal stove (thermal expulsion) in the early evenings. In the recent years, a revived interest has been observed among the health-conscious consumers with the plant-based repellents because of their low mammalian and non-target toxicity than their synthetic counterparts. Consequently, the exploding demands and falling supply insists to conduct more ethnobotanical survey in order to formulate risks-reduced/green pesticides and repellents from the traditionally used repellent plants.”

Cupressus lusitanica
Cupressus lusitanica [source: Toby Hudson, Wikimedia Commons]
The team identified 22 plants used by the local inhabitants against mosquitoes and other insect and arachnid pests, including ticks, bedbugs, and houseflies. Commonly used insect-repellent plants included Gatirra Habasha (Cupressus lusitanica), Akaakltii Adii (Eucalyptus globulus), and Bakanissa (Croton macrostachyus). A number of respondents reported using a mixture of various repellent plants stem, root, resin, leaves and bark, called Shita.

The authors note that their findings suggest “a steady decline/erosion of knowledge and practices of repellent plants,” against which ethnobotanical surveys such as this one “may serve as a connecting-link to transfer the practical knowledge and traditional practices from the older to younger generations,” and “lay the first stone to devise affordable user-friendly next generation vector control tools to minimize the vector-borne disease burden especially malaria in the near future.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Medicinal Plants Used by the Deb Barma Clan of Bangladesh

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A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh

Kabir MH, Hasan N, Rahman MM, Rahman MA, Khan JA, Hoque NT, Bhuiyan MR, Mou SM, Jahan R, Rahmatullah M
J Ethnobiol Ethnomed. 2014 Feb 6;10:19
PubMed Central PMCID: PMC3996145

Moulvibazar District, Bangladesh
Moulvibazar District, Bangladesh [source: Nafsadh, Wikimedia Commons]
Mohammad Humayun Kabir and colleagues at the University of Development Alternative conducted a survey of the ethnomedicinal practices of the Deb barma clan of the Tripura tribe, residing in Dolusora Tripura Palli of Bangladesh’s Moulvibazar district.

The survey is part of a larger project to document the medical ethnobotany of Bangladesh:

“Towards building up a comprehensive database of medicinal plants of the country and their traditional uses, we had been interviewing and documenting the traditional medicinal practices of folk and tribal medicinal practitioners for a number of years. The Tripura (also known as Tripuri, Tiprah or Tipperah) tribe is one such indigenous community in Bangladesh, whose various clans can be found in the Chittagong and Sylhet Divisions in the southeast and northeast parts, respectively, of the country. The various clans of the Tripura tribe include Deb barma (also known as Tiprah), Reang or Bru, Jamatia, Koloi, Noatia, Murasing, Halam, Harbang, and Uchoi. We have previously documented the ethnomedicinal practices of the Harbang clan of the Tripura tribal community residing in Chittagong Division of Bangladesh.”

On the basis of interviews of the tribal healer and the tribal community regarding their ethnomedicinal practices, with the help of a semi-structured questionnaire and guided field-walks, the team documented 44 medicinal plants used by the tribal healer for treatment of a variety of ailments, including malaria, skin infections, tuberculosis, respiratory disorders, bleeding from external cuts and wounds, chest pain, gastrointestinal disorders, rheumatic pain, burning sensations during urination, bone fracture, snake bite, toothache, headache, bleeding from gums, paralysis, skin disorders, helminthiasis, chicken pox, diabetes, jaundice, eye disorders and weakness.

Persicaria glabra
Persicaria glabra [source: J. M. Garg, Wikimedia Commons]
Several plants were found to be unique in their use for medicinal purposes by the Deb barma healer, including Physalis micrantha, Persicaria glabra, Smilax macrophylla, Sansevieria hyacinthoides, Garcinia cowa, Pouzolzia zeylanica and Lantana camara, and are proposed for scientific examination for their relevant pharmacological activities.

From the Conclusion:

“…In recent years, the Deb barma clan members may have started to prefer allopathic system more than their traditional medicinal system. If this happens, the ethnomedicinal wisdom of the Deb barma clan may be lost forever, if not documented. Since already the usage of a number of their traditional medicinal plants has been validated through scientific research, it is important that the yet to be studied plants be examined scientifically as to their pharmacological properties and their phytochemical constituents. Such studies can be beneficial to human beings if new and more efficacious medicines can be discovered from these plants.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Women’s Knowledge of Medicinal Plants in Madagascar’s Littoral Forest

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Medicinal plants used by women from Agnalazaha littoral forest (Southeastern Madagascar)

Razafindraibe M, Kuhlman AR, Rabarison H, Rakotoarimanana V, Rajeriarison C, Rakotoarivelo N, Randrianarivony T, Rakotoarivony F, Ludovic R, Randrianasolo A, Bussmann RW
J Ethnobiol Ethnomed. 2013 Nov 4;9:73
PubMed Central PMCID: PMC3827988

Atsimo Atsinanana Region of Madagascar
Madagascar with Atsimo Atsinanana Region highlighted [Source: Esculapio, Wikimedia Commons]
Mendrika Razafindraibe and coauthors from the University of Antananarivo and Missouri Botanical Garden conducted an ethnobotanical study to assess utilization of the Agnalazaha littoral forest by women in the commune of Mahabo-Mananivo, and to determine the diversity of medicinal plants used by them.

Agnalazaha Forest is located within the Atsimo Atsinanana region of southeastern Madagascar, and has been under the management of the Missouri Botanical Garden since 2002.

Working with 498 residents of Commune Rural Mahabo-Mananivo, the team collected 152 medicinal plants used by local people, including eight native species that were very well known and used for multiple conditions:

Nepenthes madagascariensis
Nepenthes madagascariensis [Source: Yves-Pascal Suter, Wikimedia Commons]
  • Voacanga thouarsii (used in childbirth and to treat gonorrhea, syphilis, mycosis, wounds, hypertension and stomach ulcers and for the care of the digestive tract)
  • Cinnamosma madagascariensis (for dental decay and general oral care, to treat malaria, and for care of complications after childbirth)
  • Olax emirnensis (used in childbirth and to treat malaria, hepatitis, epilepsy, dysentery and fatigue)
  • Syzygium emirnense (used in childbirth and to treat diarrhea, dental disease and scabies)
  • Nepenthes madagascariensis (used in childbirth and to treat malaria, filariasis, ear infections, syphilis and gonorrhea)
  • Phyllarthron madagascariense (to support breastfeeding and treat malaria and fatigue)
  • Suregada boiviniana (to help evacuate the placenta and treat epilepsy, dysentery and malaria)
  • Asteropeia micraster (to help evacuate the placenta and treat diarrhea, fatigue and mumps)

The authors conducted their work in the context of severe biodiversity loss (particularly of the littoral forest, of which only 10% of the original forest that once stretched 1600km along the eastern coast of Madagascar remains):

“Biodiversity loss, in general, has severe implications on environmental stability which in turn affects human health. When biodiversity directly adds to the wellness of a community as a resource for medicine, biodiversity loss can have even deeper consequences as medicinal plant species are lost or are no longer available….

“Our study found that many of the medicinal species sourced from Agnalazaha Forest were also utilized for other daily living needs. Native medicinal species may also be used as timber, construction materials, and firewood. Conservation concerns mostly lie in the overuse of these valuable daily living species. Conversations with community members highlighted the concern and interest they had for protecting the natural resource of Agnalazaha Forest while ensuring the forest could still be used. It is our goal that through careful ethnobotanical studies of the modern use of Agnalazaha Forest, we can help the community of Mahabo-Mananivo understand their forest use and establish community driven sustainable conservation plans.”

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Review of Plant-Based Insect Repellents

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Natural products for the control of malaria

Malar J. 2011 Mar 15;10 Suppl 1:S1
BioMed Central

XI. Plant-based insect repellents: a review of their efficacy, development and testing

Maia MF, Moore SJ
Malar J. 2011 Mar 15;10 Suppl 1:S11
PubMed Central PMCID: PMC3059459

Marta Ferreira Maia and Sarah J. Moore of the London School of Hygiene and Tropical Medicine and Ifakara Health Institute summarize recent information on testing, efficacy and safety of plant-based insect repellents.

From the abstract:

“Plant-based repellents have been used for generations in traditional practice as a personal protection measure against host-seeking mosquitoes. Knowledge on traditional repellent plants obtained through ethnobotanical studies is a valuable resource for the development of new natural products. Recently, commercial repellent products containing plant-based ingredients have gained increasing popularity among consumers, as these are commonly perceived as “safe” in comparison to long-established synthetic repellents although this is sometimes a misconception. To date insufficient studies have followed standard WHO Pesticide Evaluation Scheme guidelines for repellent testing. There is a need for further standardized studies in order to better evaluate repellent compounds and develop new products that offer high repellency as well as good consumer safety.”

Cymbopogon
Cymbopogon [Source: Wikimedia Commons, YosriNov04Pokok Serai]
Noting that most plants contain compounds that they use in preventing attack from plant-eating insects including mosquitoes, Ferreira Maia and Moore review several plant-based insect repellents including lemon eucalyptus (Corymbia citriodora) extract, Cymbopogon nardus, Cymbopogon winterianus, neem (Azadirachta indica), and essential oils distilled from members of the Lamiaceae, Poaceae and Pinaceae families.

The authors address some fallacies about plant-based repellents and propose considerations for testing methodologies.

They conclude with a review of promising recent developments in research on plant-based repellents.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Curcumin as a Candidate for the Treatment of Cerebral Malaria

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Natural products for the control of malaria

Malar J. 2011 Mar 15;10 Suppl 1:S1
BioMed Central

X. The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria

Mimche PN, Taramelli D, Vivas L
Malar J. 2011 Mar 15;10 Suppl 1:S10
PubMed Central PMCID: PMC3059458

Curcuma longa
Curcuma longa [Source: Wikimedia Commons, J.M.Garg]
Patrice N. Mimche of the London School of Hygiene and Tropical Medicine and Università di Milano, with coauthors Donatella Taramelli and Livia Vivas, review the properties of curcumin (Curcuma longa) and its potential as an adjunctive therapy for the management of cerebral malaria.

From the abstract:

“The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM.”

The authors review the evidence for curcumin as a modulator of the innate immune response to malaria infection, and conclude that the potential anti-malarial activity of curcumin merits investigation alongside ongoing research efforts exploring clinical applications of curcumin in chronic inflammatory disorders, diabetes and cancer.

Read the complete article at PubMed Central.

The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.