Tag Archives: oncology

Phase I Clinical Trial of Abemaciclib for Patients with Bladder Cancer

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Window of Opportunity Trial of Abemaciclib for Bladder Cancer

Weill Medical College of Cornell University / Eli Lilly and Company
ClinicalTrials.gov Identifier: NCT03837821
Abemaciclib PubChem CID: 46220502

Weill Medical College of Cornell University - New York, NY
Weill Medical College of Cornell University – New York, NY [Photo: Cornell010, Wikimedia Commons]
Investigators at Weill Medical College of Cornell University have opened a Phase I “Window of Opportunity” clinical trial of neoadjuvant abemaciclib (Verzenio®, Eli Lilly and Company) followed by radical cystectomy in patients with platinum-ineligible urothelial carcinoma (bladder cancer) to evaluate CDK4/6-dependent phosphorylation of pocket proteins and clonal evolution dynamics.

See complete details, including study location(s), eligibility criteria, contact information, and study results (when available) at ClinicalTrials.gov.

Send email to avery@williamaveryhudson.com for information about submitting qualified clinical trials for sponsored posts on this blog.




The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Phase I Study of Venetoclax Combined With Vyxeos (CPX-351) for Relapsed or Refractory Acute Leukemia

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Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia

Children’s Hospital Medical Center, Cincinnati
ClinicalTrials.gov Identifier: NCT03825289
Venetoclax PubChem CID: 11707110
Vyxeos PubChem CID: 11707110

Childrens Hospital Medical Center Cincinnati
Children’s Hospital Medical Center, Cincinnati [Photo: Cincinnati Children’s Hospital Medical Center]
Investigators at Children’s Hospital Medical Center, Cincinnati, have opened a Phase I clinical trial to study the safety and tolerability of combining venetoclax (VENCLEXTA®, AbbVie) with VYXEOS® (CPX-351, daunorubicin and cytarabine, Jazz Pharmaceuticals) in pediatric and young adult patients with acute leukemia that has come back or has not responded to treatment.

See complete details, including study location(s), eligibility criteria, contact information, and study results (when available) at ClinicalTrials.gov.

Send email to avery@williamaveryhudson.com for information about submitting qualified clinical trials for sponsored posts on this blog.




The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

Phase I Study of Trametinib and Hydroxychloroquine in Treating Patients with Pancreatic Cancer

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Trametinib and Hydroxychloroquine in Treating Patients with Pancreatic Cancer (THREAD)

University of Utah / Novartis Pharmaceuticals
ClinicalTrials.gov Identifier: NCT03825289
Trametinib PubChem CID: 11707110

Huntsman Cancer Institute, University of Utah
Huntsman Cancer Institute, University of Utah [Photo: National Cancer Institute]
Investigators at the Huntsman Cancer Institute at the University of Utah are conducting a Phase I clinical trial to study the side effects and best dose of hydroxychloroquine when given together with trametinib (MEKINIST®, Novartis) in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery.

See complete details, including study location(s), eligibility criteria, contact information, and study results (when available) at ClinicalTrials.gov.

Send email to avery@williamaveryhudson.com for information about submitting qualified clinical trials for sponsored posts on this blog.




The information on my blog is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding current medical knowledge. A physician should always be consulted for any health problem or medical condition.

OncologyWatch.com – Peer-Reviewed Journal Articles & Current Clinical Trials

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Oncology Publications & Clinical Research, Updated in Real Time

I invite you to bookmark a new website I’ve launched at OncologyWatch.com. OncologyWatch delivers updated listings of journal publications and clinical trials, updated in real time as they are published.

Two open-access references are essential to OncologyWatch: PubMed, the archive of biomedical and life sciences journal literature maintained by the US National Institutes of Health’s National Library of Medicine; and ClinicalTrials.gov, the registry and results database of publicly and privately supported clinical studies of human participants conducted around the world, also maintained by NIH.

Osteosarcoma_Cells_thumbnail
Photo: Osteosarcoma Cells (Michael Blank, Ying Zhang, NCI Center for Cancer Research)

Browse or search OncologyWatch to find your target cancer (the nomenclature mirrors that of the US National Cancer Institute’s index of cancer types). One click executes a customized search for relevant journal articles and clinical trials. Once you land on the NIH sites, you’ll have the option to further customize your searches. Filter for articles with free full text, for example, or for clinical trials in a specific geographic location.

Why I Built OncologyWatch

OncologyWatch is one of two websites that I maintain to provide information relevant to health care. My other site, A Knowledge Machine, provides a broad range of information relevant to health, art, and social progress.

The epistemological method for my websites derives from “As We May Think,” a 1945 Atlantic Monthly essay by Vannevar Bush, President Roosevelt’s science adviser during World War II. Bush’s vision led to the development of the hyperlink and the World Wide Web.

Over the past three decades, I’ve had the good fortune to work with many smart and generous colleagues in the not-for-profit and for-profit sectors who have taught me a great deal and given me the opportunity to help them weave the stuff of the future.

OncologyWatch and A Knowledge Machine reproduce and support the ongoing diligence that now informs my work as a public relations consultant for clients in health, art, and social progress organizations.

To make full use of my work, consider also following my blog posts and Twitter feed as I build my next-generation integrated web platform in support of activists for peace, sound environmental stewardship, humane economic policy, and promotion of human health and creativity.

Photo: Stress Fibers and Microtubules in Human Breast Cancer Cells (Christina Stuelten & Carole Parent, NCI Center for Cancer Research)

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